Cell fate 'decisions' involving multipotential progenitors seem to be 'dictated' by threshold activities of lineage-determining transcription factors. Such 'decisions' are now shown to be reinforced by the induction of secondary transcription factors that act in concert with the primary regulators.
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Singh, H. Shaping a helper T cell identity. Nat Immunol 8, 119–120 (2007). https://doi.org/10.1038/ni0207-119
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DOI: https://doi.org/10.1038/ni0207-119