Specific docking of the three T cell receptor complementary-determining regions (CDRs) onto the peptide-MHC complex is the basis of immune recognition. However, the contribution of each CDR to peptide-MHC binding is not routine.
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Kranz, D. T cell receptor CDRs: starring versus supporting roles. Nat Immunol 6, 130–132 (2005). https://doi.org/10.1038/ni0205-130
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DOI: https://doi.org/10.1038/ni0205-130
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