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STOP! In the name of positive selection

  • An Erratum to this article was published on 01 March 2005

Calcium signaling is essential during thymocyte development. It seems that calcium oscillations trigger thymocytes to become immotile, prolonging interactions with stromal cells that are critical for positive selection.

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References

  1. 1

    Cahalan, M.D., Parker, I., Wei, S.H. & Miller, M.J. Nat. Rev. Immunol. 2, 872–880 (2002).

  2. 2

    Bhakta, N.R., Oh, D.Y. & Lewis, R.S. Nat. Immunol. 6, 143–151 (2005).

  3. 3

    Feske, S., Giltnane, J., Dolmetsch, R., Staudt, L.M. & Rao, A. Nat. Immunol. 2, 316–324 (2001).

  4. 4

    Negulescu, P.A., Krasieva, T.B., Khan, A., Kerschbaum, H.H. & Cahalan, M.D. Immunity 4, 421–430 (1996).

  5. 5

    Donnadieu, E., Bismuth, G. & Trautmann, A. Curr. Biol. 4, 584–595 (1994).

  6. 6

    Dustin, M.L., Bromley, S.K., Kan, Z., Peterson, D.A. & Unanue, E.R. Proc. Natl. Acad. Sci. USA 94, 3909–3913 (1997).

  7. 7

    Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Science 296, 1869–1873 (2002).

  8. 8

    Miller, M.J., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 100, 2604–2609 (2003).

  9. 9

    Miller, M.J., Hejazi, A.S., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 101, 998–1003 (2004).

  10. 10

    Mempel, T.R., Henrickson, S.E. & Von Andrian, U.H. Nature 427, 154–159 (2004).

  11. 11

    Miller, M.J., Safrina, O., Parker, I. & Cahalan, M.D. J. Exp. Med. 200, 847–56 (2004).

  12. 12

    Bousso, P., Bhakta, N.R., Lewis, R.S. & Robey, E. Science 296, 1876–1880 (2002).

  13. 13

    Dolmetsch, R.E., Xu, K. & Lewis, R.S. Nature 392, 933–936 (1998).

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Figure 1: Two-photon microscopy permits tissue visualization of dye-labeled cells in a thymus slice preparation.

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