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STOP! In the name of positive selection

Nature Immunology volume 6, pages 126–128 (2005)Cite this article

An Erratum to this article was published on 01 March 2005

Calcium signaling is essential during thymocyte development. It seems that calcium oscillations trigger thymocytes to become immotile, prolonging interactions with stromal cells that are critical for positive selection.

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Figure 1: Two-photon microscopy permits tissue visualization of dye-labeled cells in a thymus slice preparation.

K.R.

References

  1. Cahalan, M.D., Parker, I., Wei, S.H. & Miller, M.J. Nat. Rev. Immunol. 2, 872–880 (2002).

    Article  CAS  Google Scholar 

  2. Bhakta, N.R., Oh, D.Y. & Lewis, R.S. Nat. Immunol. 6, 143–151 (2005).

    Article  CAS  Google Scholar 

  3. Feske, S., Giltnane, J., Dolmetsch, R., Staudt, L.M. & Rao, A. Nat. Immunol. 2, 316–324 (2001).

    Article  CAS  Google Scholar 

  4. Negulescu, P.A., Krasieva, T.B., Khan, A., Kerschbaum, H.H. & Cahalan, M.D. Immunity 4, 421–430 (1996).

    Article  CAS  Google Scholar 

  5. Donnadieu, E., Bismuth, G. & Trautmann, A. Curr. Biol. 4, 584–595 (1994).

    Article  CAS  Google Scholar 

  6. Dustin, M.L., Bromley, S.K., Kan, Z., Peterson, D.A. & Unanue, E.R. Proc. Natl. Acad. Sci. USA 94, 3909–3913 (1997).

    Article  CAS  Google Scholar 

  7. Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Science 296, 1869–1873 (2002).

    Article  CAS  Google Scholar 

  8. Miller, M.J., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 100, 2604–2609 (2003).

    Article  CAS  Google Scholar 

  9. Miller, M.J., Hejazi, A.S., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 101, 998–1003 (2004).

    Article  CAS  Google Scholar 

  10. Mempel, T.R., Henrickson, S.E. & Von Andrian, U.H. Nature 427, 154–159 (2004).

    Article  CAS  Google Scholar 

  11. Miller, M.J., Safrina, O., Parker, I. & Cahalan, M.D. J. Exp. Med. 200, 847–56 (2004).

    Article  CAS  Google Scholar 

  12. Bousso, P., Bhakta, N.R., Lewis, R.S. & Robey, E. Science 296, 1876–1880 (2002).

    Article  CAS  Google Scholar 

  13. Dolmetsch, R.E., Xu, K. & Lewis, R.S. Nature 392, 933–936 (1998).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Physiology and Biophysics, University of California, Irvine, 92697-4561, California, USA

    Michael D Cahalan

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  1. Michael D Cahalan
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Cahalan, M. STOP! In the name of positive selection. Nat Immunol 6, 126–128 (2005). https://doi.org/10.1038/ni0205-126

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