Secretion of IFN-γ by T cells is usually the result of antigen stimulation. However, a newly identified GADD45β pathway can implement IFN-γ production after exposure to cytokines IL-18 and IL-12 without need of antigen.
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Nakanishi, K. Innate and acquired activation pathways in T cells. Nat Immunol 2, 140–142 (2001). https://doi.org/10.1038/84236
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DOI: https://doi.org/10.1038/84236
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