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From immunity to tolerance through HDAC

Regulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in CD4+ T cells.

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Figure 1: A model of how the function of antigen-presenting cells is regulated by HDAC11 through Il10.

Katie Vicari


  1. Akira, S., Uematsu, S. & Takeuchi, O. Cell 124, 783–801 (2006).

    Article  CAS  Google Scholar 

  2. Li, M.O. & Flavell, R.A. Immunity 28, 468–476 (2008).

    Article  Google Scholar 

  3. Villagra, A. et al. Nat. Immunol. 10, 92–100 (2009).

    Article  CAS  Google Scholar 

  4. Ramirez-Carrozzi, V.R. et al. Genes Dev. 20, 282–296 (2006).

    Article  CAS  Google Scholar 

  5. Foster, S.L., Hargreaves, D.C. & Medzhitov, R. Nature 447, 972–978 (2007).

    Article  CAS  Google Scholar 

  6. Zhang, X., Edwards, J.P. & Mosser, D.M. J. Immunol. 177, 1282–1288 (2006).

    Article  CAS  Google Scholar 

  7. Li, B. et al. Genes Dev. 21, 1422–1430 (2007).

    Article  CAS  Google Scholar 

  8. Yang, X.J. & Seto, E. Nat. Rev. Mol. Cell Biol. 9, 206–218 (2008).

    Article  CAS  Google Scholar 

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Georgopoulos, K. From immunity to tolerance through HDAC. Nat Immunol 10, 13–14 (2009).

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