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The dual-function CD150 receptor subfamily: the viral attraction

Nature Immunologyvolume 4pages1924 (2003) | Download Citation

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Abstract

The CD150 subfamily within the CD2 family is a growing group of dual-function receptors that have within their cytoplasmic tails a characteristic signaling motif. The ITSM (immunoreceptor tyrosine-based switch motif) enables these receptors to bind to and be regulated by small SH2 domain adaptor proteins, including SH2D1A (SH2-containing adaptor protein SH2 domain protein 1A) and EAT-2 (EWS-activated transcript 2). A major signaling pathway through the prototypic receptor in this subfamily, CD150, leads to the activation of interferon-γ, a key cytokine for viral immunity. As a result, many viruses have designed strategies to usurp or alter CD150 functions. Measles virus uses CD150 as a receptor and Molluscum contagiosum virus encodes proteins that are homologous to CD150. Thus, viruses use CD150 subfamily receptors to create a favorable environment to elude detection and destruction. Understanding the CD150 subfamily may lead to new strategies for vaccine development and antiviral therapies.

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Acknowledgements

We thank members of biotechnology group of IEPOR and other colleagues for helpful discussions and H. Floyd and E. Floyd for helpful comments. Supported by INTAS grant 011-2382 (to S.P.S.), U.S. Civilian Research and Development Foundation grant UB2-531 (to S.P.S.) and National Institutes of Health Grant GM37905 (to E.A.C).

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  1. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS Ukraine, 45 Vasylkivska str., Kiev, 03022, Ukraine

    • Svetlana P. Sidorenko
  2. Departments of Microbiology and Immunology, University of Washington, Box 357242, Seattle, 98195, 1959 NE, Pacific, WA, USA

    • Edward A. Clark

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