Conventional CD8αβ participates in the activation of T cells by binding to the same peptide-MHC complex as does the TCR. A recent paper in Science shows, however, that the CD8αα form on iIELs binds TL and could alter signals from the TCR.
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Bonneville, M., Lang, F. CD8: from coreceptor to comodulator. Nat Immunol 3, 12–14 (2002). https://doi.org/10.1038/ni0102-12
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DOI: https://doi.org/10.1038/ni0102-12
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Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes
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