The newly rearranged T cell receptor on the surface of immature thymocytes must interact with not too much and not too little affinity for self-peptide–MHC ligands to allow the cell to mature and emigrate to the lymphoid periphery. Recent experiments shed new light on how the signal is perceived as “just right”.
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Yun, T., Bevan, M. The Goldilocks conditions applied to T cell development. Nat Immunol 2, 13–14 (2001). https://doi.org/10.1038/83118
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DOI: https://doi.org/10.1038/83118
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