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Polymorphisms in IFIH1: the good and the bad

Nature Immunology volume 18, pages 708709 (2017) | Download Citation

A study of polymorphisms in the sensor IFIH1 exposes the evolutionary trade-off between a robust antiviral type I interferon response and the risk of interferon-mediated inflammation.

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Author information

Affiliations

  1. Erika Della Mina and Mathieu P. Rodero are in the Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, Paris, France.

    • Erika Della Mina
    •  & Mathieu P Rodero
  2. Yanick J. Crow is in the Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, Paris, France and Sorbonne-Paris-Cité, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris, France, and Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK.

    • Yanick J Crow

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Yanick J Crow.

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DOI

https://doi.org/10.1038/ni.3765

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