Interleukin 17 is a chief orchestrator of immunity

Abstract

Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this cytokine is a central player in immunity at the sites most exposed to microorganisms. Although it has been strongly associated with immunopathology, IL-17 also has an important role in host defense. The regulation of IL-17 secretion seems to be shared among various cell types, each of which can concomitantly secrete additional products. IL-17 has only modest activity on its own; its impact in immunity arises from its synergistic action with other factors, its self-sustaining feedback loop and, in some cases, its role as a counterpart of interferon-γ (IFN-γ). Together these attributes provide a robust response against microorganisms, but they can equally contribute to immune pathology. Here we focus on a discussion of the role of IL-17 during infection.

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Figure 1: The major populations of lymphocytes that secrete IL-17, as detected by lineage marking for IL-17A17: TCRγδ+ γδ T cells, CD4+TCRαβ+ TH17 cells, CD3 ILC3s, TCR+NK1.1+ NKT cells and TCRNK1.1+ NK cells.
Figure 2: The role of IL-17 during infection.
Figure 3: The role of IL-17 at epithelial barrier sites.
Figure 4: The potential negative effects of IL-17 during tumor responses.

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Acknowledgements

M.V. receives funding via the European Union H2020 ERA project (no. 667824–EXCELLtoINNOV).

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Veldhoen, M. Interleukin 17 is a chief orchestrator of immunity. Nat Immunol 18, 612–621 (2017). https://doi.org/10.1038/ni.3742

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