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RNA-binding proteins mind the GAPs

Nature Immunology volume 18, pages 146148 (2017) | Download Citation

Increased expression of the ubiquitin ligase TRAF6 in hematopoietic stem cells promotes activity of the GTP-binding protein Cdc42 and consequent diminished function of hematopoietic stem cells by ubiquitination of the RNA-binding protein hnRNP-A1, which leads to an inability to properly process pre-mRNA encoding Cdc42-inhibitory GTPase-activating proteins.

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Author information

Affiliations

  1. Martin Turner is with the Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, UK.

    • Martin Turner
  2. Elisa Monzón-Casanova is with the Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, UK, and the Department of Biochemistry, University of Cambridge, Cambridge, UK.

    • Elisa Monzón-Casanova

Authors

  1. Search for Martin Turner in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Martin Turner.

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DOI

https://doi.org/10.1038/ni.3662

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