Regulatory T cells develop in the thymus as a distinct lineage of T cells instructed by the lineage-specifying transcription factor Foxp3. Epigenetic imprinting by the genome organizer Satb1 precedes this cell-fate 'decision' during thymocyte development.
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References
Kitagawa, Y. et al. Nat. Immunol. 18, 173–183 (2017).
Lio, C.W. & Hsieh, C.S. Immunity 28, 100–111 (2008).
Tai, X. et al. Immunity 38, 1116–1128 (2013).
Ohkura, N. et al. Immunity 37, 785–799 (2012).
Toker, A. et al. J. Immunol. 190, 3180–3188 (2013).
Hemberger, M., Dean, W. & Reik, W. Nat. Rev. Mol. Cell Biol. 10, 526–537 (2009).
Whyte, W.A. et al. Cell 153, 307–319 (2013).
Heinz, S. et al. Mol. Cell 38, 576–589 (2010).
Alvarez, J.D. et al. Genes Dev. 14, 521–535 (2000).
Beyer, M. et al. Nat. Immunol. 12, 898–907 (2011).
Cai, S., Han, H.J. & Kohwi-Shigematsu, T. Nat. Genet. 34, 42–51 (2003).
Zheng, Y. et al. Nature 463, 808–812 (2010).
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Beyer, M., Huehn, J. Epigenetic orchestration of thymic Treg cell development. Nat Immunol 18, 144–146 (2017). https://doi.org/10.1038/ni.3660
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DOI: https://doi.org/10.1038/ni.3660