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Mitochondria provide a 'complex' solution to a bacterial problem

Adaptations in the mitochondrial electron-transport chain mediate antibacterial responses in macrophages.

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Figure 1: A mitochondrial arsenal against bacteria in macrophages.

Marina Corral Spence/Nature Publishing Group


  1. 1

    Shadel, G.S. & Horvath, T.L. Cell 163, 560–569 (2015).

    CAS  Article  Google Scholar 

  2. 2

    Weinberg, S.E., Sena, L.A. & Chandel, N.S. Immunity 42, 406–417 (2015).

    CAS  Article  Google Scholar 

  3. 3

    West, A.P., Shadel, G.S. & Ghosh, S. Nat. Rev. Immunol. 11, 389–402 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Garaude, J. et al. Nat. Immunol. 17, 1037–1045 (2016).

    CAS  Article  Google Scholar 

  5. 5

    Acin-Perez, R. & Enriquez, J. A. Biochim. Biophys. Acta–Bioenerg. 1837, 444–450 (2014).

    CAS  Article  Google Scholar 

  6. 6

    Brandes, R.P., Weissmann, N. & Schröder, K. Free Radic. Biol. Med. 76, 208–226 (2014).

    CAS  Article  Google Scholar 

  7. 7

    West, A.P. et al. Nature 472, 476–480 (2011).

    CAS  Article  Google Scholar 

  8. 8

    West, A.P. et al. Nature 520, 553–557 (2015).

    Article  Google Scholar 

  9. 9

    Jabir, M.S. et al. Autophagy 11, 166–182 (2015).

    Article  Google Scholar 

  10. 10

    Andrade, W.A. et al. Cell Rep. 15, 2438–2448 (2016).

    CAS  Article  Google Scholar 

  11. 11

    Woodward, J. J., Iavarone, A. T. & Portnoy, D. A. Science 328, 1703–1705 (2010).

    CAS  Article  Google Scholar 

  12. 12

    Shaw, A.C., Goldstein, D.R. & Montgomery, R.R. Nat. Rev. Immunol. 13, 875–887 (2013).

    CAS  Article  Google Scholar 

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Correspondence to Gerald S Shadel.

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Holmbeck, M., Shadel, G. Mitochondria provide a 'complex' solution to a bacterial problem. Nat Immunol 17, 1009–1010 (2016).

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