Membrane immunoglobulin E (IgE) on germinal-center-like B cells, without engagement of IgE, uses the CD19-PI3K-Akt-IRF4 axis and the BLNK-Jnk-p38 axis, with the former used for plasma-cell differentiation and the latter used for apoptotic death.
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Kawakami, T. Differentiate or die!. Nat Immunol 17, 1007–1008 (2016). https://doi.org/10.1038/ni.3531
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DOI: https://doi.org/10.1038/ni.3531