In natural killer (NK) cells, CIS restrains a signaling pathway elicited by interleukin 15 (IL-15) that leads to activation of the kinase JAK1. Removal of CIS from NK cells increases their capacity to reduce the metastatic dissemination of breast cancer and melanoma in mice.
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Zitvogel, L., Kroemer, G. Unchaining NK cell–mediated anticancer immunosurveillance. Nat Immunol 17, 746–747 (2016). https://doi.org/10.1038/ni.3471
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DOI: https://doi.org/10.1038/ni.3471