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A dendritic cell subset designed for oral tolerance

Nature Immunology volume 17, pages 474–476 (2016)Cite this article

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Studies using genetic tools have identified the distinct dendritic cell subsets that ensure tolerance to oral antigens in the antigen-rich environment of the gut and suggest a 'division of labor' for protective immunity.

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Figure 1: mLN DC subsets in immunotolerance and protective immunity.

Katie Vicari/Nature Publishing Group

References

  1. Esterházy, D. & Mucida, D. Nat. Immunol. 17, 545–555 (2016).

    Article  Google Scholar 

  2. Hadis, U. et al. Immunity 34, 237–246 (2011).

    Article  CAS  Google Scholar 

  3. Bilate, A.M. & Lafaille, J.J. Annu. Rev. Immunol. 30, 733–758 (2012).

    Article  CAS  Google Scholar 

  4. Coombes, J.L. et al. J. Exp. Med. 204, 1757–1764 (2007).

    Article  CAS  Google Scholar 

  5. Sun, C.M. et al. J. Exp. Med. 204, 1775–1785 (2007).

    Article  CAS  Google Scholar 

  6. Mazzini, E., Massimiliano, L., Penna, G. & Rescigno, M. Immunity 40, 248–261 (2014).

    Article  CAS  Google Scholar 

  7. Murphy, T.L. et al. Annu. Rev. Immunol. doi:10.1146/annurev-immunol-032713-120204 (23 December 2015).

  8. Du Pre, M.F. et al. Gastroenterology 141, 610–620 (2011).

    Article  CAS  Google Scholar 

  9. Martínez-López, M., Iborra, S., Conde-Garrosa, R. & Sancho, D. Eur. J. Immunol. 45, 119–129 (2015).

    Article  Google Scholar 

  10. DePaolo, R.W. et al. Nature 471, 220–224 (2011).

    Article  CAS  Google Scholar 

  11. Worbs, T. et al. J. Exp. Med. 203, 519–527 (2006).

    Article  CAS  Google Scholar 

  12. Veenbergen, S. et al. Mucosal Immunol. doi:10.1038/mi.2015.118 (18 November 2015).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Reinhard Hinterleitner and Bana Jabri are in the Department of Medicine, Committee on Immunology, The University of Chicago, Chicago, Illinois, USA.,

    Reinhard Hinterleitner & Bana Jabri

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  1. Reinhard Hinterleitner
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  2. Bana Jabri
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Correspondence to Bana Jabri.

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The authors declare no competing financial interests.

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Hinterleitner, R., Jabri, B. A dendritic cell subset designed for oral tolerance. Nat Immunol 17, 474–476 (2016). https://doi.org/10.1038/ni.3435

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