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ReGLUation of cGAS

The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation.

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Figure 1: Glutamylation regulates the activity of cGAS.

Katie Vicari/Nature Publishing Group

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Correspondence to Andrea Ablasser.

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Ablasser, A. ReGLUation of cGAS. Nat Immunol 17, 347–349 (2016). https://doi.org/10.1038/ni.3397

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