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MicroRNA miR-22 drives TH17 responses in emphysema

The TH17 subset of helper T cells drives emphysema in smokers, but how these cells are elicited remains unknown. A study now links the microRNA miR-22 and the histone deacetylase HDAC4 to regulation of the activation of antigen-presenting cells after exposure to smoke.

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Figure 1: The role of miR-22 in the development of emphysema.

Kim Caesar/Nature Publishing Group


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Correspondence to Guy G Brusselle.

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Brusselle, G., Bracke, K. MicroRNA miR-22 drives TH17 responses in emphysema. Nat Immunol 16, 1109–1110 (2015).

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