Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

MicroRNA miR-22 drives TH17 responses in emphysema

The TH17 subset of helper T cells drives emphysema in smokers, but how these cells are elicited remains unknown. A study now links the microRNA miR-22 and the histone deacetylase HDAC4 to regulation of the activation of antigen-presenting cells after exposure to smoke.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: The role of miR-22 in the development of emphysema.

Kim Caesar/Nature Publishing Group

References

  1. Lozano, R. et al. Lancet 380, 2095–2128 (2012).

    Article  Google Scholar 

  2. Lu, W. et al. Nat. Immunol. 16, 1185–1194 (2015).

    Article  CAS  Google Scholar 

  3. Brusselle, G.G., Joos, G.F. & Bracke, K.R. Lancet 378, 1015–1026 (2011).

    Article  CAS  Google Scholar 

  4. Lee, S.H. et al. Nat. Med. 13, 567–569 (2007).

    Article  CAS  Google Scholar 

  5. Eustace, A. et al. Chest 139, 1089–1100 (2011).

    Article  Google Scholar 

  6. Roos, A.B. et al. Am. J. Respir. Crit. Care Med. 192, 428–437 (2015).

    Article  CAS  Google Scholar 

  7. Loth, D.W. et al. Nat. Genet. 46, 669–677 (2014).

    Article  CAS  Google Scholar 

  8. Chen, K. et al. PLoS ONE 6, e20333 (2011).

    Article  CAS  Google Scholar 

  9. Roos, A.B. et al. Am. J. Respir. Crit. Care Med. 191, 1232–1241 (2015).

    Article  CAS  Google Scholar 

  10. Agusti, A., Sobradillo, P. & Celli, B. Am. J. Respir. Crit. Care Med. 183, 1129–1137 (2011).

    Article  Google Scholar 

  11. Gaffen, S.L. et al. Nat. Rev. Immunol. 14, 585–600 (2014).

    Article  CAS  Google Scholar 

  12. Miossec, P. & Kolls, J.K. Nat. Rev. Drug Discov. 11, 763–776 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guy G Brusselle.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Brusselle, G., Bracke, K. MicroRNA miR-22 drives TH17 responses in emphysema. Nat Immunol 16, 1109–1110 (2015). https://doi.org/10.1038/ni.3295

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3295

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing