MicroRNA miR-22 drives TH17 responses in emphysema

Article metrics

The TH17 subset of helper T cells drives emphysema in smokers, but how these cells are elicited remains unknown. A study now links the microRNA miR-22 and the histone deacetylase HDAC4 to regulation of the activation of antigen-presenting cells after exposure to smoke.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The role of miR-22 in the development of emphysema.

Kim Caesar/Nature Publishing Group

References

  1. 1

    Lozano, R. et al. Lancet 380, 2095–2128 (2012).

  2. 2

    Lu, W. et al. Nat. Immunol. 16, 1185–1194 (2015).

  3. 3

    Brusselle, G.G., Joos, G.F. & Bracke, K.R. Lancet 378, 1015–1026 (2011).

  4. 4

    Lee, S.H. et al. Nat. Med. 13, 567–569 (2007).

  5. 5

    Eustace, A. et al. Chest 139, 1089–1100 (2011).

  6. 6

    Roos, A.B. et al. Am. J. Respir. Crit. Care Med. 192, 428–437 (2015).

  7. 7

    Loth, D.W. et al. Nat. Genet. 46, 669–677 (2014).

  8. 8

    Chen, K. et al. PLoS ONE 6, e20333 (2011).

  9. 9

    Roos, A.B. et al. Am. J. Respir. Crit. Care Med. 191, 1232–1241 (2015).

  10. 10

    Agusti, A., Sobradillo, P. & Celli, B. Am. J. Respir. Crit. Care Med. 183, 1129–1137 (2011).

  11. 11

    Gaffen, S.L. et al. Nat. Rev. Immunol. 14, 585–600 (2014).

  12. 12

    Miossec, P. & Kolls, J.K. Nat. Rev. Drug Discov. 11, 763–776 (2012).

Download references

Author information

Correspondence to Guy G Brusselle.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Brusselle, G., Bracke, K. MicroRNA miR-22 drives TH17 responses in emphysema. Nat Immunol 16, 1109–1110 (2015) doi:10.1038/ni.3295

Download citation

Further reading