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Reversed-polarity Treg cell TCRs provide a shock

Nature Immunology volume 16, pages 1105–1107 (2015)Cite this article

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Docking of T cell antigen receptors (TCRs) engaging complexes of peptide and major histocompatibility complex has shown the same diagonal orientation and polarity. A new study demonstrating that TCRs from regulatory T cells bind with reversed polarity challenges this dogma.

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Figure 1: TCR-peptide interactions.

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Authors and Affiliations

  1. Mark Peakman is in the Department of Immunobiology, King's College London, London, UK.,

    Mark Peakman

  2. Andrew K. Sewell is in the Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.,

    Andrew K Sewell

Authors
  1. Mark Peakman
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  2. Andrew K Sewell
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Corresponding authors

Correspondence to Mark Peakman or Andrew K Sewell.

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Competing interests

M.P. and King's College London have a license agreement with UCB Pharma to develop a peptide-based immunotherapy for type 1 diabetes.

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Peakman, M., Sewell, A. Reversed-polarity Treg cell TCRs provide a shock. Nat Immunol 16, 1105–1107 (2015). https://doi.org/10.1038/ni.3289

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