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Genomics is rapidly advancing precision medicine for immunological disorders

Nature Immunology volume 16, pages 10011004 (2015) | Download Citation

Advances in human genomics, when validated functionally, can lead to new insights into how the immune system works. Notably, previously unknown mechanisms revealed by genomics can lead to the development of precision medicine unanticipated on the basis of phenotype alone.

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Acknowledgements

Supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (US National Institutes of Health).

Author information

Affiliations

  1. Yu Zhang is with Human Immunological Diseases Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, and Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

    • Yu Zhang
  2. Helen C. Su is with Human Immunological Diseases Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, and National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

    • Helen C Su
  3. Michael J. Lenardo is with National Institute of Allergy and Infectious Diseases Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, and Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

    • Michael J Lenardo

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michael J Lenardo.

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DOI

https://doi.org/10.1038/ni.3275

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