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Reading the fine print: sequence-specific activation of cGAS

Nature Immunology volume 16, pages 10091010 (2015) | Download Citation

A unique guanosine-flanked Y-form DNA triggers innate cGAS-dependent responses that lead to upregulation of the production of type I interferons.

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Author information

Affiliations

  1. Jessica J. Chiang is in the Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

    • Jessica J Chiang
  2. Michaela U. Gack is in the Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA, and the Department of Microbiology, University of Chicago, Chicago, Illinois, USA.

    • Michaela U Gack

Authors

  1. Search for Jessica J Chiang in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michaela U Gack.

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DOI

https://doi.org/10.1038/ni.3274

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