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Subversion of anticancer immunosurveillance by radiotherapy

Nature Immunology volume 16, pages 10051007 (2015) | Download Citation

Paradoxically, radiotherapy can reinforce immunosuppressive pathways that undermine anticancer immunosurveillance and treatment efficacy. Irradiation induces Langerhans cells to migrate from the skin to lymph nodes, where they stimulate regulatory T cells.

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Author information

Affiliations

  1. Laurence Zitvogel is with the Gustave Roussy Cancer Campus, Villejuif, France; Inserm U1015, Villejuif, France, Université Paris Sud-XI, Faculté de Médecine, Le Kremlin Bicêtre, France; and the Center of Clinical Investigations in Biotherapies of Cancer 507, Villejuif, France.

    • Laurence Zitvogel
  2. Guido Kroemer is with Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Inserm U1138, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publiques–Hôpitaux de Paris, Paris, France; and Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.

    • Guido Kroemer

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Laurence Zitvogel.

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DOI

https://doi.org/10.1038/ni.3236

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