The anti-inflammatory molecule A20 inhibits necroptotic cell death by inhibiting ubiquitination of the kinase RIPK3 at the Lys5 residue and preventing excessive formation of the RIPK1-RIPK3 necroptotic complex.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Immunological consequences of kidney cell death
Cell Death & Disease Open Access 25 January 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Vicari/Nature Publishing Group
References
Onizawa, M. et al. Nat. Immunol. 16, 618–627 (2015).
Lee, E.G. et al. Science 289, 2350–2354 (2000).
Catrysse, L., Vereecke, L., Beyaert, R. & van Loo, G. Trends Immunol. 35, 22–31 (2014).
Giordano, M. et al. Proc. Natl. Acad. Sci. USA 111, 11115–11120 (2014).
Düwel, M. et al. J. Immunol. 182, 7718–7728 (2009).
Vande Walle, L. et al. Nature 512, 69–73 (2014).
Dillon, C.P. et al. Cell Rep. 1, 401–407 (2012).
Oberst, A. et al. Nature 471, 363–367 (2011).
Wertz, I.E. et al. Nature 430, 694–699 (2004).
Ma, A. & Malynn, B.A. Nat. Rev. Immunol. 12, 774–785 (2012).
Vandenabeele, P., Grootjans, S., Callewaert, N. & Takahashi, N. Cell Death Differ. 20, 185–187 (2013).
Sun, L. et al. Cell 148, 213–227 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Gurung, P., Man, S. & Kanneganti, TD. A20 is a regulator of necroptosis. Nat Immunol 16, 596–597 (2015). https://doi.org/10.1038/ni.3174
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3174
This article is cited by
-
Immunological consequences of kidney cell death
Cell Death & Disease (2018)
