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PTENtiating autoimmunity through Treg cell deregulation

Nature Immunology volume 16, pages 139140 (2015) | Download Citation

Regulatory T cells require the phosphatase PTEN to maintain suppressive function in homeostatic conditions through preserved expression of CD25 and the transcription factor Foxp3.

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Author information

Affiliations

  1. John P. Ray is in the Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

    • John P Ray
  2. Joe Craft is in the Department of Immunobiology and Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, Connecticut, USA.

    • Joe Craft

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Joe Craft.

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DOI

https://doi.org/10.1038/ni.3082

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