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RNA exosomes keep endogenous RNA under the radar

Nature Immunology volume 15, pages 830831 (2014) | Download Citation

The unfolded protein response produces modified endogenous RNA substrates for host cytosolic sensors of RNA, which may lead to production of the interferons IFN-α and IFN-β. The accrual of modified RNA is prevented by an RNA nuclease.

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Author information

Affiliations

  1. Yaming Wang and Marco Colonna are with the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

    • Yaming Wang
    •  & Marco Colonna

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Marco Colonna.

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DOI

https://doi.org/10.1038/ni.2966

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