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c-Myc and AP4: a relay team for metabolic reprogramming of CD8+ T cells

Nature Immunology volume 15, pages 828829 (2014) | Download Citation

AP4, a transcription factor induced by the functionally related transcription factor c-Myc, maintains the cellular metabolic program for the sustained activation and population expansion of CD8+ T cells after the dynamic loss of c-Myc expression.

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References

  1. 1.

    , , & Science 342, 1242454 (2013).

  2. 2.

    et al. Immunity 35, 871–882 (2011).

  3. 3.

    et al. Cell 151, 68–79 (2012).

  4. 4.

    et al. Nat. Immunol. 15, 884–893 (2014).

  5. 5.

    & Cell Cycle 8, 982–989 (2009).

  6. 6.

    et al. Nat. Immunol. 14, 500–508 (2013).

  7. 7.

    Nat. Rev. Immunol. 12, 325–338 (2012).

  8. 8.

    et al. Immunity 39, 1043–1056 (2013).

  9. 9.

    et al. Nature 460, 108–112 (2009).

  10. 10.

    et al. Nature 460, 103–107 (2009).

  11. 11.

    , , & Immunity 32, 67–78 (2010).

  12. 12.

    & Proc. Natl. Acad. Sci. USA 108, 14873–14878 (2011).

Download references

Author information

Affiliations

  1. Peer W.F. Karmaus and Hongbo Chi are in the Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

    • Peer W F Karmaus
    •  & Hongbo Chi

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Hongbo Chi.

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DOI

https://doi.org/10.1038/ni.2962

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