The transcription factors TCF-1 and LEF-1 have diverse roles in differentiation into the CD4+ lineage through means both dependent on and independent of the transcription factor Th-POK.
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Mookerjee-Basu, J., Kappes, D. New ingredients for brewing CD4+T (cells): TCF-1 and LEF-1. Nat Immunol 15, 593–594 (2014). https://doi.org/10.1038/ni.2927
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DOI: https://doi.org/10.1038/ni.2927
