The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.
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Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
Nature Communications Open Access 23 April 2019
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I thank S. Nanda, C. Emmerich and K. Clark for suggestions and A. Nicoll for assistance in preparing the manuscript. Supported by a Wellcome Trust Senior Investigator award (WT100294), the UK Medical Research Council (MRC_MR/K000985/1), AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Janssen Pharmaceuticals, Merck-Serono and Pfizer.
The author declares no competing financial interests.
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Cohen, P. Immune diseases caused by mutations in kinases and components of the ubiquitin system. Nat Immunol 15, 521–529 (2014). https://doi.org/10.1038/ni.2892
High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry–based deubiquitylating enzyme assay for drug discovery
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