CTLA-4 is a potent inhibitor of T cell population expansion. The PIX-GIT2-PAK2 complex is recruited to the cytoplasmic domain of CTLA-4 via the kinase PKC-η, which suggests a previously unrecognized aspect of signal transduction via CTLA-4 in immunoregulation.
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Wülfing, C., Tunbridge, H. & Wraith, D. New inhibitory signaling by CTLA-4. Nat Immunol 15, 408–409 (2014). https://doi.org/10.1038/ni.2870