Commentary | Published:

Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease

Nature Immunology volume 15, pages 307310 (2014) | Download Citation

This Commentary discusses how treatment with antibiotics in infancy shapes host immunity and influences susceptibility later in life to diseases mediated by the immune system.

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Acknowledgements

Supported by the US National Institutes of Health (DK044319, DK051362, DK053056 and DK088199 to R.S.B.), the Harvard Digestive Diseases Center (DK0034854 to R.S.B.), the European Research Council (Starting Grant Agreement 336528 to S.Z.), Deutsche Forschungsgemeinschaft (ZE814/4-1, ZE814/5-1 and ZE814/6-1, and the Excellence Cluster 'Inflammation at Interfaces', to S.Z.) and the European Commission (Marie Curie International Reintegration Grant 256363 to S.Z.).

Author information

Affiliations

  1. Sebastian Zeissig is in the Department of Internal Medicine, University Medical Center Schleswig-Holstein, Kiel, Germany.

    • Sebastian Zeissig
  2. Richard S. Blumberg is in the Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

    • Richard S Blumberg

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Richard S Blumberg.

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DOI

https://doi.org/10.1038/ni.2847

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