Precursor cells entering the thymus have non-T cell potential, yet T cell development is clearly favored. A mechanism dedicated to repressing conflicting myeloid cell fate early during the establishment of T cell identity has now been found.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bhandoola, A. Immunity 26, 678–689 (2007).
De Obaldia, M.E. et al. Nat. Immunol. 14, 1277–1284 (2013).
Cobaleda, C., Jochum, W. & Busslinger, M. Nature 449, 473–477 (2007).
Kondo, M., Weissman, I.L. & Akashi, K. Cell 91, 661–672 (1997).
Akashi, K., Traver, D., Miyamoto, T. & Weissman, I.L. Nature 404, 193–197 (2000).
Bell, J.J. & Bhandoola, A. Nature 452, 764–767 (2008).
Wendorff, A.A. et al. Immunity 33, 671–684 (2010).
Klinakis, A. et al. Nature 473, 230–233 (2011).
Kueh, H.Y., Champhekhar, A., Nutt, S.L., Elowitz, M.B. & Rothenberg, E.V. Science 341, 670–673 (2013).
Ikawa, T., Kawamoto, H., Goldrath, A.W. & Murre, C. J. Exp. Med. 203, 1329–1342 (2006).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Bortnick, A., Murre, C. A HESitant decision for T cells. Nat Immunol 14, 1209–1210 (2013). https://doi.org/10.1038/ni.2765
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.2765
