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IL-1 signaling in atherosclerosis: sibling rivalry

Nature Immunology volume 14, pages 10301032 (2013) | Download Citation

Signaling via the interleukin 1 (IL-1) family, particularly by IL-1β, has long been linked to the pathogenesis of atherosclerosis. Findings that atherogenic fatty acids induce IL-1α to promote vascular inflammation identify a key role for this less-well-studied cytokine.

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Author information

Affiliations

  1. Frederick J. Sheedy is with the Institute of Molecular Medicine, Trinity College, St. James' Hospital, Dublin, Ireland.

    • Frederick J Sheedy
  2. Kathryn J. Moore is with the Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA.

    • Kathryn J Moore

Authors

  1. Search for Frederick J Sheedy in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Kathryn J Moore.

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DOI

https://doi.org/10.1038/ni.2711

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