Immune surveillance by the liver

Abstract

Receiving both portal vein blood and arterial blood, the liver is an important and critical component in the defense against blood-borne infection. To accomplish this role, the liver contains numerous innate and adaptive immune cells that specialize in detection and capture of pathogens from the blood. Further, these immune cells participate in coordinated immune responses leading to pathogen clearance, leukocyte recruitment and antigen presentation to lymphocytes within the vasculature. Finally, this role in host defense must be tightly regulated to ensure that inappropriate immune responses are not raised against nonpathogenic exogenous blood-borne molecules, such as those derived from food. It is this balance between activation and tolerance that characterizes the liver as a frontline immunological organ.

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Figure 1: Immune constituents of the liver.
Figure 2: T cell activation by liver-resident cells.
Figure 3: Innate immune responses in the liver.

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Acknowledgements

We are grateful to W.-Y. Lee and C. Wong (Monash University, Australia) for providing the intravital microscopy images and movie used in this paper.

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Correspondence to Paul Kubes.

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Supplementary information

Rapid target capture by Kupffer cells under flow conditions.

Intravital microscopy of the liver of a C57BL/6 mouse. After intravenous injection of inert, fluorescent microspheres (green) F4/80-labeled Kupffer cells (blue) are seen to capture the particles from the circulation under shear conditions. (MOV 1803 kb)

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Jenne, C., Kubes, P. Immune surveillance by the liver. Nat Immunol 14, 996–1006 (2013). https://doi.org/10.1038/ni.2691

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