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PLA2G3 promotes mast cell maturation and function

Nature Immunology volume 14, pages 527529 (2013) | Download Citation

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The mast cell–derived phospholipase PLA2G3 and fibroblast prostaglandin synthase contribute to a mast cell–fibroblast paracrine axis dependent on the prostaglandin PGD2 and its receptor DP1 that can enhance the maturation and mediator secretion of mast cells.

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Author information

Affiliations

  1. Philipp Starkl, Thomas Marichal and Stephen J. Galli are in the Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

    • Philipp Starkl
    • , Thomas Marichal
    •  & Stephen J Galli
  2. Stephen J. Galli is in the Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.

    • Stephen J Galli

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Stephen J Galli.

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DOI

https://doi.org/10.1038/ni.2612

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