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Slc7a5 helps T cells get with the program

Nature Immunology volume 14, pages 422424 (2013) | Download Citation

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T cell activation requires an influx of amino acids. Slc7a5, an amino-acid transporter induced by the T cell antigen receptor, facilitates the influx of large neutral amino acids and in doing so promotes metabolic reprogramming necessary for T cell differentiation.

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Author information

Affiliations

  1. Jonathan D. Powell is in the Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

    • Jonathan D Powell

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Jonathan D Powell.

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DOI

https://doi.org/10.1038/ni.2594

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