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A complement a day keeps the Fox(p3) away

Nature Immunology volume 14, pages 110–112 (2013)Cite this article

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Signaling via the complement factors C3a and C5a regulates effector T cell responses. Evidence now links the absence of local complement activation with a default pathway that leads to the polarization of Foxp3+ regulatory T cells.

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Figure 1: Opposing functional phenotypes of CD4+ T cells activated in the presence or absence of local complement.

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Authors and Affiliations

  1. Gaelle Le Friec and Claudia Kemper are in the Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, King's College London, Guy's Hospital, London, UK.,

    Gaelle Le Friec & Claudia Kemper

  2. and the Division of Cellular and Molecular Immunology, Jörg Köhl is with the Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.,

    Jörg Köhl

Authors
  1. Gaelle Le Friec
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  2. Jörg Köhl
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  3. Claudia Kemper
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Correspondence to Claudia Kemper.

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The authors declare no competing financial interests.

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Le Friec, G., Köhl, J. & Kemper, C. A complement a day keeps the Fox(p3) away. Nat Immunol 14, 110–112 (2013). https://doi.org/10.1038/ni.2515

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