Maintenance of the peripheral naive CD8+ T cell pool depends on T cell antigen receptor (TCR) signals and interleukin 7 (IL-7). TCR signaling limits the duration of IL-7 signals to avoid an interferon-γ-mediated mechanism of apoptotic death of naive CD8+ T cells.
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Onodera, A., Tumes, D. & Nakayama, T. Too much of a good thing. Nat Immunol 14, 112–114 (2013). https://doi.org/10.1038/ni.2510
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DOI: https://doi.org/10.1038/ni.2510
