Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TBK1 suppression of IgA in the NIK of time

Nature Immunology volume 13, pages 1027–1029 (2012)Cite this article

Subjects

The kinase TBK1 participates in signaling pathways that induce antimicrobial responses. TBK1 is also necessary for the suppression of excessive production of immunoglobulin A by accelerating destruction of the kinase NIK.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Constitutive and regulated destruction of NIK modulates IgA production in B cells.

Debbie Maizels

References

  1. Jin, J. et al. Nat. Immunol. 13, 1101–1109 (2012).

    Article  CAS  Google Scholar 

  2. Macpherson, A.J., Geuking, M.B. & McCoy, K.D. Trends Immunol. 33, 160–167 (2012).

    Article  CAS  Google Scholar 

  3. Mora, J.R. & von Andrian, U.H. Mucosal Immunol. 1, 96–109 (2008).

    Article  CAS  Google Scholar 

  4. Wang, N. et al. Mol. Med. 17, 1383–1396 (2011).

    Article  CAS  Google Scholar 

  5. Chorny, A., Puga, I. & Cerutti, A. Adv. Immunol. 107, 31–69 (2010).

    Article  CAS  Google Scholar 

  6. Thu, Y.M. & Richmond, A. Cytokine Growth Factor Rev. 21, 213–226 (2010).

    Article  CAS  Google Scholar 

  7. Sanjo, H., Zajonc, D.M., Braden, R., Norris, P.S. & Ware, C.F. J. Biol. Chem. 285, 17148–17155 (2010).

    Article  CAS  Google Scholar 

  8. Häcker, H. & Karin, M. Sci. STKE 2006, re13 (2006).

    Article  Google Scholar 

  9. Wolf, A.I. et al. J. Clin. Invest. 121, 3954–3964 (2011).

    Article  CAS  Google Scholar 

  10. Shen, R.R. & Hahn, W.C. Oncogene 30, 631–641 (2011).

    Article  CAS  Google Scholar 

  11. Pilli, M. et al. Immunity 37, 223–234 (2012).

    Article  CAS  Google Scholar 

  12. Marchlik, E. et al. J. Leukoc. Biol. 88, 1171–1180 (2010).

    Article  CAS  Google Scholar 

  13. Herman, M. et al. J. Exp. Med. 209, 1567–1582 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Richard J. Bram is in the Department of Pediatric and Adolescent Medicine, Mayo Clinic Foundation, Rochester, Minnesota, USA.,

    Richard J Bram

Authors
  1. Richard J Bram
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard J Bram.

Ethics declarations

Competing interests

R.J.B. is listed as a coinventor on patents related to the gene encoding TACI.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bram, R. TBK1 suppression of IgA in the NIK of time. Nat Immunol 13, 1027–1029 (2012). https://doi.org/10.1038/ni.2451

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2451

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing