Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The ubiquitous nature of IL-17

The deubiquitinating enzyme USP25 restricts ubiquitination of the adaptors TRAF5 and TRAF6 and signaling via interleukin 17 and thus joins several ubiquitin-modifying enzymes already known to regulate this biomedically important pathway.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: USP25 restricts the ubiquitination of TRAF5 and TRAF6 during signaling via IL-17R.

Debbie Maizels

References

  1. Gaffen, S.L. Curr. Opin. Immunol. 23, 613–619 (2011).

    Article  CAS  Google Scholar 

  2. Spits, H. & Di Santo, J.P. Nat. Immunol. 12, 21–27 (2011).

    Article  CAS  Google Scholar 

  3. Zhong, B. et al. Nat. Immunol. 12, 1110–1117 (2012).

    Article  Google Scholar 

  4. Zepp, J.A. et al. J. Immunol. 189, 33–37 (2012).

    Article  CAS  Google Scholar 

  5. Sun, D. et al. Nat. Immunol. 12, 853–860 (2011).

    Article  CAS  Google Scholar 

  6. Bulek, K. et al. Nat. Immunol. 12, 844–852 (2011).

    Article  CAS  Google Scholar 

  7. Chen, Z.J. Immunol. Rev. 246, 95–106 (2012).

    Article  Google Scholar 

  8. Wiener, R., Zhang, X., Wang, T. & Wolberger, C. Nature 483, 618–622 (2012).

    Article  CAS  Google Scholar 

  9. Shembade, N., Ma, A. & Harhaj, E. Science 327, 1135–1139 (2010).

    Article  CAS  Google Scholar 

  10. Meulmeester, E., Kunze, M., Hsiao, H.H., Urlaub, H. & Melchior, F. Mol. Cell 30, 610–619 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Averil I Ma.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ma, A. The ubiquitous nature of IL-17. Nat Immunol 13, 1034–1035 (2012). https://doi.org/10.1038/ni.2448

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2448

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing