The transcription factor Aiolos is upregulated in T lymphocytes in a manner dependent on the transcription factors STAT3 and AhR and leads to epigenetic silencing of the gene encoding interleukin 2. This acts as a cell-intrinsic safeguard mechanism for the differentiation of helper T cells into the TH17 subset.
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Monticelli, S., Sallusto, F. Negative regulators take center stage. Nat Immunol 13, 719–720 (2012). https://doi.org/10.1038/ni.2377
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DOI: https://doi.org/10.1038/ni.2377
