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Breaking the barrier: membrane fusion triggers innate antiviral immunity

Nature Immunology volume 13, pages 713–715 (2012)Cite this article

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The sensing of viral infection by the innate immune system is dominated by the recognition of nucleic acids. New data now demonstrate that the fusion of viral and target-cell membranes leads to the activation of an immune response dependent on the adaptor STING.

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Figure 1: Fusion of the viral membrane with the host-cell membrane triggers an intrinsic antiviral response that is dependent on STING.

Katie Vicari

References

  1. Brennan, K. & Bowie, A.G. Curr. Opin. Microbiol. 13, 503–507 (2010).

    Article  CAS  Google Scholar 

  2. Holm, C.K. et al. Nat. Immunol. 13, 737–743 (2012).

    Article  CAS  Google Scholar 

  3. Kawai, T. & Akira, S. Immunity 34, 637–650 (2011).

    Article  CAS  Google Scholar 

  4. Loo, Y.M. & Gale, M. Jr. Immunity 34, 680–692 (2011).

    Article  CAS  Google Scholar 

  5. Keating, S.E., Baran, M. & Bowie, A.G. Trends Immunol. 32, 574–581 (2011).

    Article  CAS  Google Scholar 

  6. Rathinam, V.A. et al. Nat. Immunol. 11, 395–402 (2010).

    Article  CAS  Google Scholar 

  7. Noyce, R.S. et al. J. Virol. 85, 10926–10931 (2011).

    Article  CAS  Google Scholar 

  8. Zhong, B. et al. Immunity 29, 538–550 (2008).

    Article  CAS  Google Scholar 

  9. Ishikawa, H. & Barber, G.N. Nature 455, 674–678 (2008).

    Article  CAS  Google Scholar 

  10. Ishikawa, H., Ma, Z. & Barber, G.N. Nature 461, 788–792 (2009).

    Article  CAS  Google Scholar 

  11. Cheshenko, N. et al. J. Cell Biol. 163, 283–293 (2003).

    Article  CAS  Google Scholar 

  12. Dong, B. et al. J. Virol. 78, 8983–8993 (2004).

    Article  CAS  Google Scholar 

  13. Gonzalez-Dosal, R. et al. PLoS Pathog. 7, e1002250 (2011).

    Article  CAS  Google Scholar 

  14. Gross, O., Thomas, C.J., Guarda, G. & Tschopp, J. Immunol. Rev. 243, 136–151 (2011).

    Article  CAS  Google Scholar 

  15. Morgan, M.J. & Liu, Z.G. Cell Res. 21, 103–115 (2011).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. David Olagnier and John Hiscott are in the Division of Infectious Diseases, Vaccine & Gene Therapy Institute of Florida, Port St. Lucie, Florida, USA.,

    David Olagnier & John Hiscott

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  1. David Olagnier
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  2. John Hiscott
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Correspondence to John Hiscott.

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The authors declare no competing financial interests.

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Olagnier, D., Hiscott, J. Breaking the barrier: membrane fusion triggers innate antiviral immunity. Nat Immunol 13, 713–715 (2012). https://doi.org/10.1038/ni.2373

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