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Tespa1: another gatekeeper for positive selection

Nature Immunology volume 13, pages 530–532 (2012)Cite this article

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A previously unknown protein, Tespa1, that regulates the thymocyte positive-selection checkpoint has now been identified. The phenotype of Tespa1-deficient mice and the role of Tespa1 in thymocyte signaling are very similar to those of Themis-deficient mice and Themis itself, another recently described but unrelated protein.

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Figure 1: Tespa1 interactions in thymocyte signaling.

References

  1. Wang, D. et al. Nat. Immunol. 13, 560–568 (2012).

    Article  CAS  PubMed  Google Scholar 

  2. Fu, G. et al. Nat. Immunol. 10, 848–856 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Johnson, A.L. et al. Nat. Immunol. 10, 831–839 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lesourne, R. et al. Nat. Immunol. 10, 840–847 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Patrick, M.S. et al. Proc. Natl. Acad. Sci. USA 106, 16345–16350 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Kakugawa, K. et al. Mol. Cell. Biol. 29, 5128–5135 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Brockmeyer, C. et al. J. Biol. Chem. 286, 7535–7547 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Jang, I.K. et al. Proc. Natl. Acad. Sci. USA 107, 10620–10625 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Fujimoto, T. et al. Biochem. Biophys. Res. Commun. 408, 214–217 (2011).

    Article  CAS  PubMed  Google Scholar 

  10. Fujimoto, T. et al. Biochem. Biophys. Res. Commun. 408, 282–286 (2011).

    Article  CAS  PubMed  Google Scholar 

  11. Morris, G.P. & Allen, P.M. Nat. Immunol. 13, 121–128 (2012).

    Article  CAS  PubMed  Google Scholar 

  12. Freedman, B.D., Liu, Q.H., Somersan, S., Kotlikoff, M.I. & Punt, J.A. J. Exp. Med. 190, 943–952 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Nicholas R.J. Gascoigne and Guo Fu are in the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,

    Nicholas R J Gascoigne & Guo Fu

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  1. Nicholas R J Gascoigne
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  2. Guo Fu
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Correspondence to Nicholas R J Gascoigne.

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The authors declare no competing financial interests.

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Gascoigne, N., Fu, G. Tespa1: another gatekeeper for positive selection. Nat Immunol 13, 530–532 (2012). https://doi.org/10.1038/ni.2315

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