Interleukin-17 (IL-17) induces the recruitment of neutrophils to sites of inflammation. In a model of periodontitis, Del-1 is now described to be an inhibitor of IL-17 expression that suppresses the recruitment of neutrophils and the associated inflammation-mediated pathology.
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References
Khader, S.A., Gaffen, S.L. & Kolls, J.K.T. Mucosal Immunol. 2, 403–411 (2009).
Eskan, M.A. et al. Nat. Immunol. 13, 465–473 (2012).
Yu, J.J. et al. Blood 109, 3794–3802 (2007).
Gaffen, S.L. & Hajishengallis, G. J. Dent. Res. 87, 817–828 (2008).
Liang, S., Hosur, K.B., Domon, H. & Hajishengallis, G. J. Periodontal Res. 45, 574–578 (2010).
Choi, E.Y. et al. Science 322, 1101–1104 (2008).
Kolls, J.K. & Khader, S.A. Cytokine Growth Factor Rev. 21, 443–448 (2010).
Reynolds, J.M., Angkasekwinai, P. & Dong, C. Cytokine Growth Factor Rev. 21, 413–423 (2010).
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Khader, S. Restraining IL-17: Del-1 deals the blow. Nat Immunol 13, 433–435 (2012). https://doi.org/10.1038/ni.2290
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DOI: https://doi.org/10.1038/ni.2290