Two studies identify a tissue-autonomous innate immune mechanism whereby infection provokes epithelial cells to produce IL-17C that engages an epithelial receptor composed of IL-17RA and IL-17RE chains, which promotes host defense and immune activation.
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References
Rutherford, J. in Identity, Community, Culture, Difference (ed. Rutherford, J.) 211 (Lawrence and Wishart, London, 1990).
Ramirez-Carozzi, V. et al. Nat. Immunol. 12, 1159–1166 (2011).
Song, X. et al. Nat. Immunol. 12, 1151–1158 (2011).
Chang, S.H. et al. Immunity published online, doi:10.1016/j.immuni.2011.09.010 (6 October 2011).
Fossier, F. et al. J. Exp. Med. 183, 2593–2603 (1996).
Harrington, L.E., Mangan, P.R. & Weaver, C.T. Curr. Opin. Immunol. 18, 349–356 (2006).
Ribot, J.C. et al. Nat. Immunol. 10, 427–436 (2009).
Sutton, C.E. et al. Immunity 31, 331–341 (2009).
Shibata, K., Yamada, H., Hara, H., Kishihara, K. & Yoshikai, Y. J. Immunol. 178, 4466–4472 (2007).
Puel, A. et al. Science 332, 65–68 (2011).
Duerr, R.H. et al. Science 314, 1461–1463 (2006).
Swamy, M., Jamora, C., Havran, W. & Hayday, A. Nat. Immunol. 11, 656–665 (2010).
Zheng, Y. et al. Nat. Med. 14, 282–289 (2008).
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Swamy, M., Hayday, A. Provocative exhibits at the Seventeen Gallery. Nat Immunol 12, 1131–1133 (2011). https://doi.org/10.1038/ni.2164
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DOI: https://doi.org/10.1038/ni.2164
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