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Damage control: how HIV survives the editor APOBEC3G

Nature Immunology volume 12, pages 925927 (2011) | Download Citation

The antiviral factor APOBEC3G upregulates the expression of ligands for the activating receptor NKG2D via DNA damage induced by the viral protein Vpr in cells infected with human immunodeficiency virus. The virus overcomes greater susceptibility to natural killer cell–mediated lysis by targeting APOBEC3G for degradation.

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Author information

Affiliations

  1. J. Ludovic Croxford and Stephan Gasser are with the Immunology Programme, Department of Microbiology, National University of Singapore, Singapore.

    • J Ludovic Croxford
    •  & Stephan Gasser

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Stephan Gasser.

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DOI

https://doi.org/10.1038/ni.2115

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