The antiviral factor APOBEC3G upregulates the expression of ligands for the activating receptor NKG2D via DNA damage induced by the viral protein Vpr in cells infected with human immunodeficiency virus. The virus overcomes greater susceptibility to natural killer cell–mediated lysis by targeting APOBEC3G for degradation.
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Croxford, J., Gasser, S. Damage control: how HIV survives the editor APOBEC3G. Nat Immunol 12, 925–927 (2011). https://doi.org/10.1038/ni.2115
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DOI: https://doi.org/10.1038/ni.2115
