IL-17R signaling: new players get in on the Act1

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Proinflammatory signaling by the interleukin 17 receptor requires the adaptor Act1. Two studies identify an additional function for Act1 and identify new participants that regulate the inflammatory effects of IL-17.

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Figure 1: TRAF6-dependent and TRAF6-independent IL-17R signaling pathways.

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Correspondence to Michael J May.

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