Innate immune responses need to be tightly controlled to avoid autoimmune and inflammatory diseases. The atypical orphan nuclear receptor SHP has now been identified as a negative regulator of Toll-like receptor–induced activation of the transcription factor NF-κB.
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Beyaert, R. SHP works a double shift to control TLR signaling. Nat Immunol 12, 725–727 (2011). https://doi.org/10.1038/ni.2075
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DOI: https://doi.org/10.1038/ni.2075
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