Where, in antiviral defense, does IFIT1 fit?

New data show that the interferon-induced gene product IFIT1 is a sensor for 5′-triphosphorylated RNA of viral origin and that it functions within a larger IFIT complex to inhibit viral replication.

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Figure 1: The IFIT1 complex inhibits viral replication.

Katie Vicari

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Correspondence to Veit Hornung.

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Ablasser, A., Hornung, V. Where, in antiviral defense, does IFIT1 fit?. Nat Immunol 12, 588–590 (2011). https://doi.org/10.1038/ni.2061

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